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Mandy Moore
As patient Mary Portman, Moore used to be portray for notion to be one of the dramatic episodes in Grey’s history (and that’s the explanation announcing loads): the Seattle Grace Mercy West capturing. She returned the following season for a surgical course of; her personality died after slipping into a coma. (Seasons 6 and 7.)
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Faye Dunaway
She performed the first female surgeon at Seattle Grace Successfully being facility, Dr. Margaret Campbell. After botching a surgical operation—and then repairing it—she determined to retire. (Season 5.)
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Jennifer Westfeldt
After by chance working over her husband and bringing him to the health heart, a pregnant Jen (moreover the personality’s identify) collapsed and later had a seizure attributable to an aneurysm. She went into surgical operation, all the most realistic most likely device by which she used to be given a blood transfusion that attach her pregnancy at serious risk. Within the kill, she died and the limited one lived. (Season 5.)
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Constance Zimmer
The Home of Cards and Entourage actress performed Dr. Cahill, a doctor introduced in to offer the health heart lag more efficiently. (Season 9.)
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Christina Ricci
She performed a paramedic who had to aid her hand on a damage lest she detonate a bomb that used to be within the patient. Yes, certainly. (Season 2.)
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Jurnee Smollett-Bell
As Beth Monroe, she came to the health heart with an inoperable tumor and used to be the first patient to outlive Derek and Meredith’s clinical trial. Her boyfriend Jeremy used to be moreover section of the trial; he died. (Season 4.)
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Kyle Chandler
He used to be the head of the bomb squad and died searching to raise the bomb out of the health heart. (Season 2.)
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Abigail Breslin
The Dinky Miss Sunshine and Cry Queens indispensable particular person performed a limited bit girl who used to be resistant to feeling any anguish. (Season 3.)
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Elisabeth Moss
The Livid Males and Handmaid’s Epic indispensable particular person performed an overprotective and pretty unhinged daughter whose mom suffered from a situation that triggered bone to grow at the placement of an damage. The mom died in surgical operation. (Season 3.)
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Jesse Plemons
The Friday Night Lights alumnus performed Jake Burton, a young man with craniodiaphyseal dysplasia. The bone dysfunction, “lionitus,” causes calcium to create up within the cranium, leading to facial disfiguration. In Jake’s case, the growth moved inward as effectively, and Derek used to be tasked with eradicating the following mind tumor. Jake died in surgical operation. (Season 2.)
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Zach Gilford
FNL indispensable particular person Gilford performed a lieutenant within the U.S. Navy who came to the health heart with terrifying leg anguish, soliciting for an amputation. Despite the undeniable truth that she would possibly maybe presumably obtain nothing depraved with the leg, Callie Torres agreed to assemble the surgical operation so he would possibly maybe presumably return to energetic responsibility. (Season 5.)
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Sarah Chalke
The Scrubs actress performed the mom of a sick boy whom Jo Wilson wrongly recognized with strep throat. The limited one in actuality had a uncommon coronary heart situation, Kawasaki illness, which Jo caught wonderful in time to prevent eternal damage, mainly attributable to the boy’s power mom. (Season 9.)
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Michaela Watkins
She performed Nikki, a lady who fell out of a tree, the establish she used to be stationed to note on her ex-boyfriend, then refused to enjoy surgical operation attributable to superstition. She died. (Season 2.)
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Katie Lowes
She performed a blood donor within the portray’s seventh season and went on to enjoy a principal greater characteristic within the Shondaverse as Quinn on Scandal.
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Alexandra Billings
The Clear indispensable particular person plays Donna Gibson, a trans girl who used to be recognized with breast most cancers. (Season 3.)
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Ken Marino
Marino performed Brad, a man who actually dodged a bullet when a disgruntled ex-employee confirmed up at his restaurant with a gun. Brad used to be leaving the health heart when Petey looked all over again—and this time killed him. (Season 2.)
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Maggie Siff
The Sons of Anarchy indispensable particular person performed Ruthie, a lady with severe osteoporosis triggered by malnutrition. (She’d misplaced 40 pounds to fulfill her boyfriend’s criteria for transferring in together.) She died after vomiting up blood attributable to a bleeding ulcer. (Season 4.)
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Danny Stable
The Buffy and Gilmore Girls indispensable particular person (and TV and picture writer) performed Paul, a man who notion he used to be meeting his girlfriend’s cat—and it turned out that her cat used to be a lion. (Season 8.)
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Leslie Odom Jr.
Sooner than turning into a Broadway god as Aaron Burr in Hamilton, Odom performed a young man who begrudgingly agreed to donate a kidney to his father. (Season 5.)
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Rich Sommer
The Livid Males indispensable particular person performed a driver’s ed teacher who saved his girlfriend’s son’s lifestyles by getting him to the health heart in time. (Season 12.)
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Doris Roberts
The leisurely, substantial Everyone Loves Raymond matriarch performed a patient with lung most cancers who donated $200,000 to Alex Karev’s African orphans initiatives. (Season 7.)
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Bernadette Peters
As Sarabeth, Peters and her associates were on their scheme to the Fire and Ice Ball when their limo crashed. She stumbled on out her husband used to be cheating on her, nonetheless nobody died. (Season 5.)
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Seth Inexperienced
Inexperienced’s two-episode arc ended along with his personality dying; he had a tumor on his carotid artery. (Season 4.)
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June Squibb
The old fashioned actress, who’s these days blessed Girls and Shameless with her presence, performed Elsie Clatch, a 95-yr-venerable girl who undergoes surgical operation for a mind bleed and dies, leaving within the abet of her husband of a long time. (Season 13.)
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Heather Matarazzo
The Welcome to the Dollhouse and Princess Diaries actress performed a lady who survives a tunnel cave in. What makes it that a ways more intense used to be that she used to be in labor and on her scheme to the health heart when the accident took location. (Season 11.)
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Laurie Metcalf
Metcalf performed a lady with terminal most cancers who had but to portray her young daughter she used to be sick. (Season 2.)
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Scott Foley
The Felicity and Scandal indispensable particular person had a routine characteristic as Teddy Altman’s husband, whom she met within the health heart when he used to be her patient. (Season 7 and 8.)
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Geena Davis
The A League of Their Hold tale performed Dr. Nicole Herman, a surgeon with most efficient six months to dwell who chose to direct about a of her rarest medical wisdom onto Arizona Robbins. (Season 11.)
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Dylan Minnette
Sooner than 13 Causes Why, Minnette performed a precocious limited one named Ryan, who used to be born with most efficient within ear parts and confirmed up to Seattle Grace to inquire Price Sloan to create him ears without cost. (Season 4.)
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Frances Conroy
The Six Ft Below indispensable particular person performed a lady who purposely ran her car into a laundromat after seeing her estranged husband’s mistress by the window. She mistakenly admitted her crime to the doctors, thinking they couldn’t portray the police attributable to confidentiality regulations. (Season 7.)
