HealthDay Reporter
MONDAY, Aug. 16, 2021 (HealthDay Info) — COVID-19 vaccination triggers a solid immune response in of us with HIV, meaning they’re seemingly protected against the coronavirus, a brand unique, tiny review exhibits.
“Old review has on the spot a suboptimal response to COVID-19 vaccines in of us living with HIV; nonetheless, these reviews did not absolutely symbolize and description that response, both for cell [where the immune system directly attacks infected cells] and humoral [where the immune system circulates virus-fighting antibodies] immunity,” acknowledged senior review author Dr. Joel Blankson. He is a professor of medication on the Johns Hopkins College College of Medicines, in Baltimore.
“What we came upon with the generally light Pfizer/BioNTech vaccine was once exact the opposite, because it induces sturdy immune responses in of us living with HIV, equal to those seen in healthy of us,” he defined in a Hopkins recordsdata release.
For the review, Blankson and his colleagues analyzed blood samples light from seven ladies and five men with HIV and from seven ladies and 10 men without HIV between seven and 17 days after they obtained their 2d dose of the two-dose Pfizer vaccine.
None of the contributors had evidence of prior infection with the coronavirus (SARS-CoV-2) that causes COVID-19.
The total of us with HIV were on antiretroviral therapy and had a median CD4+ T-cell depend of 913 cells per microliter. Phases of these immune cells in a healthy grownup are between 500 to 1,200 cells per microliter, whereas of us with untreated HIV would possibly maybe well well presumably impartial possess counts lower than 200 cells per microliter.
CD4+ T-cells are sometimes called helper T-cells because they support one more vogue of immune cell known as B-cells in responding to surface proteins (antigens) on viruses equivalent to SARS-CoV-2, the researchers defined.
The researchers also checked for the presence and ranges of antibodies against the protein making up the spikes that protrude from the outside of the coronavirus within the contributors after they’d been absolutely vaccinated.
“We came upon that there was once no most essential incompatibility in either the vaccine-produced CD4+ T-cell responses or the titers [levels] of SARS-CoV-2 spike binding antibodies for healthy contributors and those living with HIV,” Blankson acknowledged. “This indicates that folks living with HIV would possibly maybe well also be adequately protected against SARS-CoV-2, with impartial vaccination.”
The review was once published on-line no longer too long within the past within the journal Clinical Infectious Diseases.
Extra review is wanted to win out if of us with HIV who possess lower CD4+ T-cell counts assemble the same solid cell and humoral immune responses to COVID-19 vaccines as the contributors on this review, Blankson acknowledged.
More recordsdata
HIV.gov has extra on COVID-19 and of us with HIV.
SOURCE: Johns Hopkins Medicines, recordsdata release, Aug. 11, 2021
