Alzheimer’s Tau Vaccine; Anosmia and COVID-19; Ketamine for MS Fatigue

An Alzheimer’s vaccine candidate designed to generate a particular antibody response in opposition to pathologic phospho-tau (p-tau) proteins developed to phase Ib/II scientific trials, AC Immune announced.

Steady EEG did no longer reinforce mortality in significantly sick sufferers with altered consciousness more than routine EEG, a randomized trial confirmed. (JAMA Neurology)

Ladies smokers were four instances as doubtless as non-smokers to harbor an unruptured intracranial aneurysm. (Journal of Neurology Neurosurgery & Psychiatry)

And among women folks in narrate, concussion became as soon as linked to an elevated likelihood of subsequent hyperactivity disorder, dementia, Parkinson’s disease, and mood and fear concerns. (Family Medication and Community Health)

An infection of non-neuronal cell forms within the upper nasal cavity could perhaps also lead to anosmia in COVID-19 sufferers, a mouse imprint urged. (Science Advances)

One other case portray described a affected person with Guillain-Barré syndrome preceded by COVID-19, further raising the potential of a causal relationship. (Neurology Scientific Observe)

Of us born after 1929 had decrease dementia incidence than of us born earlier; neither childhood socioeconomic web page nor later-life vascular likelihood looked as if it would fable for this. (JAMA Community Originate)

A fresh smartphone app that lets sufferers personalize neuromodulation therapies for power misfortune, Parkinson’s disease, and well-known tremor won FDA approval, tool maker Abbott said.

Low-dose infusion of the anesthetic ketamine could perhaps also wait on contend with lengthy-term fatigue in multiple sclerosis sufferers, a tiny phase I/II trial urged. (More than one Sclerosis Journal)

Of us with epilepsy had a 2.5 instances bigger hazard of incident dementia, a retrospective imprint in Wales confirmed. (Neurology)

An oral solution of calcium, magnesium, potassium, and sodium oxybates (Xywav) became as soon as authorised to address cataplexy and excessive daytime sleepiness in narcolepsy sufferers, Jazz Pharmaceuticals announced.

Labels for prescription opioid painkillers and opioid exercise disorder medication will doubtless be required to encompass info about the overdose-reversal drug naloxone, the FDA said.

CDC plans to update its 2016 opioid prescribing pointers and opened a register for public comments.

Can plasma exchange with albumin change unhurried cognitive and functional decline in Alzheimer’s disease? The phase IIb/III AMBAR imprint confirmed potential. (Alzheimer’s & Dementia)